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蔡有光
 蔡有光老師
  • 職稱: 副教授
  • 學歷:  M.D. (Medicine), National Taiwan University;Ph.D. (Biochemistry), Michigan State University
  • 辦公室: 圖資大樓 六樓 R645 室
  • 電話: 886-2-28267119
  • Email:  這個 E-mail 地址已經被防止灌水惡意程式保護,您需要啟用 Java Script 才能觀看
  • 個人網頁
  • 研究領域--以蛋白質後轉譯修飾基與蛋白質複合體分析技術為基礎的轉譯醫學研究
  • Biomarker research: Identification of plasma protein modifications as biomarkers of major human diseases, such as cancers and chronic diseases
  • Drug discovery research: Identification and characterization of protein complexomic changes responsible for pathogenesis of diseases, such as cancers and viral infections
  • Drug discovery research: Application of proteomics methods to development of pharmacodynamics assays
  • Drug discovery research: Development of mass spectrometry-based platforms for characterization of protein therapeutics
  • 研究著作
    • Yu YT, Chien SC, Chen IY, Lai CT, Tsay YG, Chang SC, Chang MF. (2016) Surface vimentin is critical for the cell entry of SARS-CoV. J Biomed Sci. 22;23:14. doi: 10.1186/s12929-016-0234-7.

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    • Li JJ, Lan KL, Chang SF, Chen YF, Tsai WC, Chiang PH, Lin MH, Fischer WB, Shih YS, Yen SH, Liu RS, Tsay YG, Wang HE, Chang CA. (2015) Development and Characterization of the Recombinant Human VEGF-EGF Dual-Targeting Fusion Protein as a Drug Delivery System. Bioconjug Chem. 26(12):2481-96.

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    • Liu NY, Lee HH, Chang ZF, Tsay YG*. (2015) Examination of segmental average mass spectra from liquid chromatography-tandem mass spectrometric (LC-MS/MS) data enables screening of multiple types of protein modifications. Anal Chim Acta. 892:115-22.

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    • Huang CY, Chen WM, Tsay YG, Hsieh SC, Lin Y, Lee WJ, Sheu WH, Chiang AN. (2015) Differential regulation of protein expression in response to polyunsaturated fatty acids in the liver of apoE-knockout mice and in HepG2 cells. J Biomed Sci. 22:12.

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    • Weng RR, Shu HW, Chin SW, Kao Y, Chen TW, Liao CC, Tsay YG, Ng WV. (2014) OMICS in ecology: systems level analyses of Halobacterium salinarum reveal large-scale temperature-mediated changes and a requirement of CctA for thermotolerance. OMICS. 18(1):65-80.

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      • Weng RR, Chu LJ, Shu HW, Wu TH, Chen MC, Chang Y, Tsai YS, Wilson MC, Tsay YG, Goodlett DR, Ng WV. (2013) Large precursor tolerance database search - a simple approach for estimation of the amount of spectra with precursor mass shifts in proteomic data. J Proteomics. 91:375-84.

       

      • Chen YF, Chang CA, Lin YH, Tsay YG. (2013) Determination of accurate protein monoisotopic mass with the most abundant mass measurable using high-resolution mass spectrometry. Anal Biochem. 440(1):108-113.

       

      • Huang C, Jiang JY, Chang SC, Tsay YG, Chen MR, Chang MF. (2013) Nuclear export signal-interacting protein forms complexes with lamin A/C-Nups to mediate the CRM1-independent nuclear export of large hepatitis delta antigen. J Virol. 87(3):1596-604.

       

      • 黃彥鈞, 蔡有光 (2013) 從分子生物學的定義談起. 科學月刊. 44卷1期 119-125頁

       

      • Chang CA, Wang IF, Lee HY, Meng CN, Liu KY, Chen YF, Yang TH, Wang YM, Tsay YG. (2012) The formation stability, hydrolytic behavior, mass spectrometry, DFT study, and luminescence properties of trivalent lanthanide complexes of H2ODO2A. Dalton Trans. 41(48):14697-706.

       

      • Chang YH, Lee SH, Chang HC, Tseng YL, Lai WW, Liao CC, Tsay YG, Liao PC. (2012) Comparative secretome analyses using a hollow fiber culture system with label-free quantitative proteomics indicates the influence of PARK7 on cell proliferation and migration/invasion in lung adenocarcinoma. J Proteome Res. 11(11):5167-85.

       

      • Huang YL, Chung TW, Chang CM, Chen CH, Liao CC, Tsay YG, Shaw GC, Liaw SH, Sun CM, Lin CH. (2012) Qualitative analysis of the fluorophosphonate-based chemical probes using the serine hydrolases from mouse liver and poly-3-hydroxybutyrate depolymerase (PhaZ) from Bacillus thuringiensis. Anal Bioanal Chem. 404(8):2387-96.

       

      • Lai JH, She TF, Juang YM, Tsay YG, Huang AH, Yu SL, Chen JJ, Lai CC. (2012) Comparative proteomic profiling of human lung adenocarcinoma cells (CL 1-0) expressing miR-372. Electrophoresis. 33(4):675-88.

       

      • Chuang HH, Yang CH, Tsay YG, Hsu CY, Tseng LM, Chang ZF, Lee HH. (2012) ROCKII Ser1366 phosphorylation reflects the activation status. Biochem J. 443(1):145-51.

       

      • Shih YY, Nakagawara A, Lee H, Juan HF, Jeng YM, Lin DT, Yang YL, Tsay YG, Huang MC, Pan CY, Hsu WM, Liao YF. (2012) Calreticulin mediates nerve growth factor-induced neuronal differentiation. J Mol Neurosci. 47(3):571-81.

       

      • Shih YY, Lee H, Nakagawara A, Juan HF, Jeng YM, Tsay YG, Lin DT, Hsieh FJ, Pan CY, Hsu WM, Liao YF. (2011) Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma. PLoS One. 6(10):e26236.

       

      • Liao KA, Tsay YG, Huang LC, Huang HY, Li CF, Wu TF. (2011) Search for the tumor-associated proteins of oral squamous cell carcinoma collected in Taiwan using proteomics strategy. J Proteome Res. 10(5):2347-58.

       

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